Patient Li, male, 52 years old, diagnosed with lung cancer for more than four years, repeated many times in many hospitals for radiotherapy and chemotherapy.In August 2012, the patient appeared with head and neck swelling, panic and shortness of breath, abdominal distension, chest CT showed stenosis of superior vena cava, and was admitted to a hospital for treatment of right lung moderately differentiated squamous carcinoma with superior vena cava syndrome after radiotherapy, and at that time, infusion was chosen to be performed in the inguinal area for three days by femoral venous placement (CVC), which was forced to be extubated due to inability to tolerate, and later treatment was completed by superficial venous puncture in the lower limbs. At that time, CVC was performed in the groin area for three days, but the patient could not tolerate it and was forced to be extubated. This time, the patient was admitted to the hospital with obvious swelling of the head and neck, cyanosis, panic and shortness of breath, abdominal distension worsened compared with the previous one, and chemotherapy was needed as soon as possible, but the patient could not see any blood vessels in both lower limbs that could be punctured for infusion. After careful evaluation of the patient’s vascular condition under ultrasound, we decided to place the PICC catheter from the patient’s femoral vein and move the puncture point from the original groin area down to the middle of the thigh, which did not affect the activities and was easy to use and maintain. This decision was quickly agreed by the doctor, the patient and his family, and then the patient was placed in the PICC special placement room, operated by the head nurse Gao Zhulin, assisted by Long Jing and Liu Jia, to assess the blood vessels again, measure the length, disinfection, toweling, puncture, delivery of the tube, fixation, and try to infuse fluids, 50 minutes passed, and a PICC catheter was placed from the femoral vein of the patient’s right middle thigh to the inferior vena cava (which was verified by radiographs). film verification), the patient was very happy, he said, “I can receive chemotherapy today, I’m saved.” PICC cannulation is usually placed from the elbow or elbow of the upper limb, but clinically, some patients with lung cancer and malignant lymphoma will encounter superior vena cava syndrome, which is caused by tumor compression of the superior vena cava to the right atrium of the blood flow is partially or completely blocked for the establishment of venous access for this type of patients need to avoid the upper limb venous infusion is usually the choice of the femoral vein, in the past, there is no ultrasound guidance, the femoral vein puncture site is located in the groin and femur, the femoral vein puncture site is located in the groin and femur. In the past, without ultrasound guidance, the femoral vein puncture site was located in the inguinal region, which had the disadvantages of limiting lower limb movement, more complications, and difficult care. Ultrasound-guided placement of PICC catheter from the thigh can effectively avoid the bending activities of the thigh in the groin, and the patient’s activities are not restricted during the catheterization period, and the patient only needs to remove the trouser sutures on the inner thigh or wear shorts when intravenous infusion is given. This operation opens up a new way of thinking for patients with superior vena cava syndrome to establish a safe, effective and long-lasting intravenous access, which is the first case in our province.