Collagenase Ointment is best for treating burn disease and it is recommended to follow the doctor’s instructions and use the medication under the guidance of a professional. Collagenase Ointment is a whitish or yellowish ointment that is primarily used for enzymatic debridement of burn wounds and to promote wound healing. The drug may cause adverse reactions such as localized pain, burning or stinging sensation. Silver and mercury in detergents and antiseptics can reduce the activity of collagenase ointment, and care should be taken not to combine it with these to avoid failing to achieve therapeutic results. Before applying collagenase ointment, wash the affected area gently with saline; in case of infection, the affected area can be treated with an appropriate antibiotic, such as penicillin, before applying collagenase ointment. If the infection persists and does not go away, suspend the use of collagenase ointment and wait until the infection clears up before continuing to use the medication.