The specific survival period of congenital syphilis babies is related to the degree of illness and development of the child. Congenital syphilis infants refers to the presence of syphilis spirochetes in the body of pregnant women during pregnancy, syphilis spirochetes can enter the baby’s body through the placenta, pregnant women are prone to miscarriages in the 20th to 35th week of pregnancy, and syphilis spirochetes will affect the development of the baby, resulting in deformity of the baby died shortly after birth. Congenital syphilis babies can be cured if they are born at term, have fewer complications after birth, and receive regular antisyphilis treatment in a timely manner. Congenital syphilis infants usually show loose skin, underweight, runny nose, hoarse voice, etc. It is important to pay close attention to all the vital signs of the infant and actively pursue treatment. Congenital syphilis infants must be timely and regular treatment, to avoid untimely treatment of life-threatening children.