When you go to bed with flatulence, you can choose local massage and other physical therapy and take drugs such as domperidone to relieve and treat it. 1. Physical therapy: you can massage the abdomen with suitable strength before going to bed, stimulate the gastrointestinal tract to cause gastrointestinal peristalsis to increase; you can also carry out local hot compresses, the elevation of temperature caused by the acceleration of local blood circulation, local metabolism to speed up, so as to alleviate the symptoms of abdominal pain, abdominal distension and other symptoms. 2.Drug treatment: (1) Promote gastric power drugs: domperidone, mosapride, etc. can increase peristalsis of the gastrointestinal tract and promote gastric emptying, so as to achieve the effect of promoting gastrointestinal power, which can relieve abdominal distension, nausea, vomiting, heartburn and other symptoms. (2) Acid inhibitors: pantoprazole, omeprazole, lansoprazole, etc. can irreversibly covalently bind with the proton pump of the stomach wall cells, thus leading to partial inactivation of the proton pump and inhibiting gastric acid secretion, thus relieving acid reflux, gastric pain, gastric bloating and other symptoms caused by excessive gastric acid secretion. It is recommended to consult a doctor for a clear diagnosis and targeted treatment of flatulence while sleeping. In addition, all of the above medications should be taken under the guidance of a doctor and should not be used without authorization.