Sacubitril valsartan can be taken before and after meals, twice a day, starting with a small dose and gradually increasing the dose of the drug. Sacubitril valsartan belongs to the treatment of heart failure drugs, including sacubitril and valsartan two ingredients, the former mainly acts on the enkephalinase, can increase the concentration of brain natriuretic peptide in the body, the latter belongs to the angiotensin II receptor antagonist, can alleviate the symptoms of patients with heart failure, is suitable for the long-term treatment of chronic heart failure patients. Sacubitril valsartan can be taken before and after meals, the effect of the drug is not affected by food, try to start with a small dose, and gradually increase the dose according to the condition of the patient, heart failure patients need to take the drug twice a day, in order to effectively play the role of anti-heart failure. Adverse reactions of sacubatril valsartan include dizziness, headache, hypotension, impaired renal function, etc. A very small number of patients may experience skin rash, hyperkalemia, etc. Allergy to drug components, lactating pregnant women, hepatic insufficiency, severe renal impairment, diabetic patients who are taking oral aliskiren are contraindicated. When patients with heart failure are treated with oral sacubitril valsartan, they should use the drug under the guidance of a doctor and choose the appropriate dose.