Parkinson’s disease is also known as “tremor palsy”. Parkinson’s disease is a degenerative disease of the nervous system that commonly occurs in middle-aged and elderly people, mostly around the age of 60. It is characterized by slow movements, tremors in the arms and legs or other parts of the body, and a loss of flexibility and stiffness. Parkinson’s disease is the fourth most common neurodegenerative disease in older adults, with 1% of those aged ≥65 years suffering from the disease; and 0.4% of those aged >40 years. The disease can also develop in childhood or adolescence. In fact, Parkinson’s disease is a common and frequent clinical disease in neurology, but unfortunately it is often misdiagnosed, some patients do not receive timely treatment, some patients are diagnosed but there are irregular medication and poor treatment, and patients suffer from long-term pain. As a result, some patients have a combination of anxiety and depression, which aggravates the clinical symptoms of patients. To know early if you have Parkinson’s disease, it is important to understand the early manifestations of the disease and what are the first signs of the disease. Parkinson’s disease differential diagnosis 1, Parkinson’s syndrome: Parkinson’s syndrome is often secondary to some other diseases of the nervous system, including cerebrovascular disease, traumatic brain injury, intracranial inflammation, brain tumors, or caused by toxic substances, drugs, so Parkinson’s syndrome is also called “secondary Parkinson’s disease”. In addition, there are also symptomatic Parkinson’s syndromes, which are essentially other neurological diseases with some symptoms of Parkinson’s disease, also known as “Parkinson’s superimposed syndrome”. The clinical manifestations of Parkinson’s syndrome and Parkinson’s disease Parkinson’s disease ≠ Parkinson’s syndrome. In terms of onset, Parkinson’s syndrome can occur in any age group, unlike Parkinson’s disease, which usually starts in middle and old age. Clinically, Parkinson’s syndrome has the same manifestations as Parkinson’s disease, such as motor retardation, dull expression, increased muscle tone, tremor, etc. In addition, it often has manifestations left over from the primary disease, such as seizure disorder, hemiparesis, headache, ataxia, oculomotor disorder, slurred speech, postural hypotension, dementia, etc. The imaging manifestations of Parkinson’s disease are not characteristic. 2, idiopathic tremor: a dominant genetic disease, manifested as involuntary tremor of the head, jaw, limbs, tremor frequency can be high or low, high frequency is very similar to hyperthyroidism; low frequency is very similar to Parkinson’s tremor. The disease does not have reduced movement, increased muscle tone, and postural reflex disorder, and disappears after drinking alcohol, and can be differentiated from primary Parkinson’s disease. 3, Parkinson’s superimposed syndrome: this disease also occurs in middle-aged and elderly, clinical symptoms can have muscle tonicity, tremor and other extrapyramidal symptoms. However, this disease has prominent eye gaze disorder, muscle tonicity to the trunk, light involvement of limb muscles and better maintain the flexibility of the limbs, increased tension of neck extensor muscles resulting in cervical hyperextension and Parkinson’s disease neck flexion is obviously different, can be distinguished from Parkinson’s disease. 4, drug Parkinson’s syndrome: overdose of reserpine, chlorpromazine, haloperidol and other antidepressant drugs can cause extrapyramidal symptoms, because there is a clear history of drug use, and after discontinuation of the drug to reduce can be distinguished.