Sodium fructose diphosphate and cetirizine are usually taken at intervals of about 80 minutes. 1.Sodium fructose bisphosphate is an intermediate product of glycolysis, which can activate phosphofructokinase and pyruvate kinase in cells to regulate enzymatic reactions. It is mainly used as an adjunctive treatment for myocardial ischemia, angina pectoris and other diseases. The drug reaches its peak concentration in 5 minutes of use and is completely metabolized in 80 minutes. After taking the drug, abdominal distension, nausea, palpitations and other discomfort may occur. The drug is contraindicated for those who are allergic to the components of the drug and those with kidney failure. Secondly, it is necessary to pay attention to the fact that patients with severe ulcers should take the drug after meals. Pregnant and lactating women should use the drug under the guidance of a doctor. 2. Cetirizine belongs to the selective Zuan H1 receptor antagonist, mainly used for seasonal rhinitis, allergic rhinitis, allergic conjunctivitis and other diseases treatment. Usually, it reaches the peak blood concentration 30-60 minutes after taking it, thus seeing the effect, and will be completely excreted from the urine in about 10 hours. Secondly, headache, drowsiness, dry mouth, nausea and other discomforts may occur after taking the drug. It is contraindicated for those who are allergic to the components of the drug and those with severe renal impairment. In the process of taking the drug, it is necessary to pay attention to monitoring kidney function, and should not be able to drive vehicles and operate machinery, while pregnant women and lactating women need to use the drug under the guidance of a doctor. In summary, sodium fructose diphosphate needs about 80 minutes to be fully metabolized, so the interval time with cetirizine is about 80 minutes. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.