Total bilirubin 40 mostly belongs to mild jaundice, which is not serious for the degree of jaundice, but other factors should be integrated to determine whether the overall condition is serious. Total bilirubin includes direct bilirubin and indirect bilirubin. Elevated direct bilirubin mostly indicates hepatocellular destruction or bile duct obstruction, so if total bilirubin 40 is mainly direct bilirubin, the cause should be further identified and liver function should be monitored dynamically, and if bilirubin continues to rise, the condition should be treated as soon as possible. If indirect bilirubin is elevated, hemolysis and abnormal bilirubin metabolic pathway are most likely to be seen. 40-plus interstitial bile is not a very high value, but continued elevation should be treated promptly.