The causes of splenomegaly are as follows: 1. chronic diseases, including connective tissue disease, immune system diseases, portal hypertension, anemia, etc., which can lead to an enlarged spleen. 2. cirrhosis of the liver, which can lead to an enlarged spleen due to an abnormal response to venous blood return from the liver. 3. leukemia, which can lead to an enlarged hematopoietic function due to massive hematopoiesis. 4. 4. Acute infections, including viral, bacterial and spirochete infections, can stimulate the patient’s immune system, making it necessary for the spleen to produce a large number of cells to resist the virus, resulting in a significant condition of the spleen, which is best diagnosed by going to the hospital for appropriate tests.