Aggravation of coughing at night can be caused by a variety of reasons and needs to be treated separately according to respiratory, circulatory and digestive disorders. The specific treatment should be determined according to the respective conditions. 1. Respiratory system: the common diseases that cause aggravation of cough at night, such as cough variant asthma, often at night or early in the morning coughing is the main, the treatment is mainly to inhalation of glucocorticoids combined with adrenergic agonists, such as budesonide formoterol inhaler is the main, and at the same time, can be used with the addition of leukotriene receptor antagonist such as menglustat and so on treatment. 2. Circulatory system: mainly heart failure, which can cause pulmonary stasis and coughing, and the symptoms are more serious after lying down at night. Treatment can be used to enhance myocardial contractility drugs such as digoxin, diuretics such as furosemide and so on to alleviate the symptoms. 3. Digestive system: mainly refers to gastroesophageal reflux disease (GERD), cough aggravated at night after lying down with a full meal due to the reflux of gastric juices to stimulate the esophagus and the trachea, the treatment is mainly used to inhibit the acidity of medicines such as omeprazole and gastric power medicines such as mosapride for treatment. Besides, cough aggravation at night can be caused by other diseases, such as nasal diseases. If the symptoms are not relieved or aggravated, it is recommended to consult a doctor in a timely manner. The specific cause of the cough should be clarified after medical examination, and the medication should be used according to the doctor’s instructions.