The headache may be related to severe migraine, subarachnoid hemorrhage, meningitis and other causes, need to be on the cause of the drug treatment, surgical treatment. 1. Severe migraine headache caused by severe headache, patients are often accompanied by nausea, vomiting, photophobia, fatigue and other symptoms, can be prescribed oral ibuprofen or aspirin and other non-steroidal anti-inflammatory drugs, zolmitriptan and other tretinoin drugs to relieve pain. 2. Severe headache caused by subarachnoid hemorrhage is mostly unilateral and sudden onset, often accompanied by nausea, vomiting, neck stiffness and other symptoms. Patients can take calcium ion blocker drugs such as nimodipine to reduce vasospasm, use mannitol and other dehydrating agents to reduce cranial pressure, and if necessary, surgery to drain the cerebrospinal fluid and remove the hematoma. 3. In severe headache caused by meningitis, patients may also have fever, nausea, vomiting, neck stiffness and other symptoms. Antiviral drugs and antibiotics can be given to suppress inflammation; if complications such as hydrocephalus and hemorrhagic stroke occur, craniotomy is needed. It is recommended that people with severe headache should consult a doctor in time to clarify the cause of the disease and standardize the treatment under the doctor’s guidance.