Maligment melanoma of uvea is the most common malignant intraocular tumor in adults, accounting for the highest incidence of intraocular tumors in foreign countries and the second most common intraocular tumor in China after retinoblastoma. This tumor is highly malignant, easily metastasized via blood stream, and is more common in adults, and is easily confused with many fundus diseases in clinical work. Therefore, it should be given full attention in the clinical work of ophthalmology. The disease is more common in middle-aged and older patients. The posterior pole of the eye is the site of prevalence, and the incidence decreases in the forward direction. Differential diagnosis 1. Choroidal nevus: Choroidal nevus is a benign tumor. Most of them are stable and do not develop. Occasionally, it may affect its adjacent tissues, but malignancy is rare. 2. Choroidal hemangioma: Choroidal hemangioma is a benign tumor that usually occurs between 10-20 years of age. They can exist alone or can be part of the manifestation of craniofacial hemangioma, often combined with glaucoma. Histologically, these tumors are spongy and microscopically up to 90% are complicated by retinal detachment. Clinical manifestations: poor vision, which can be part of the presentation of craniofacial hemangioma, often combined with glaucoma. 3. Choroidal metastases. 4, wet age-related macular degeneration. 5, choroidal hemorrhage: choroidal hemorrhage has important clinical significance. Regardless of the amount of hemorrhage, it can lead to permanent visual impairment due to its damage to the retina, especially if it is located in the macula. Localized choroidal hemorrhage, which is also confined to the choroid, presents as a dark red, nodular or round mass of varying size with retinal vessels passing over the surface and a smoky gray or white retina in that area, with dark spots in the visual field at corresponding locations. If the hemorrhage involves the macula, there is a significant loss of central vision. The hemorrhage resorption process is slow and usually lasts for several months. The permanent scar that remains is slightly smaller than the initial hemorrhagic mass, and residual choroidal white fibers and irregular pigmented masses are visible, which appear as blind areas in the visual field at the corresponding locations.