Whether yellowing of the hands and face is serious or not depends on the etiology of the onset. When yellowing of the hands and face is visible to the naked eye, the following two factors are considered: First, moderate to severe anemia: patients with decreased hemoglobin will have a bloodless and waxy face. Routine blood tests are preferred to determine the presence and degree of anemia, and then the causes of anemia are examined for comprehensive treatment. Second, jaundice: When yellowing of the hands and face is visible to the naked eye, bilirubin is above 34.2 μmol/L, mostly due to various causes of liver injury, obstructive jaundice or hemolytic jaundice. A comprehensive assessment of the condition is required, taking into account the patient’s underlying medical history, symptoms, signs and ancillary tests. The higher the jaundice, the more severe the condition, and the clinical assessment of improvement or deterioration is based on the rise and fall of jaundice. When jaundice due to liver injury factors exceeds 171 μmol/L and prothrombin activity is less than 40%, the diagnosis is hepatic necrosis, which is a very dangerous condition with a very high mortality rate. Therefore, when yellow hands, yellow face, and deepening urine color are detected, it is important to pay high attention, seek immediate medical attention, and promote recovery under the guidance of a doctor with medication and lifestyle adjustments.