There are many reasons for the dry cracked and hard skinned palms, such as vitamin deficiency, ringworm, keratosis pilaris, palmoplantar keratosis, etc. In addition to paying attention to hand moisturizing, you also need to choose to use different medications according to the cause of the disease. 1. Vitamin deficiency: when the body lacks vitamins can lead to dry cracked palms and hard skin, but appropriate supplemental vitamins, such as vitamin C, vitamin B complex and so on. 2. Ringworm: hand infection fungus can cause ringworm, resulting in dry cracked palms with hard skin, you can use topical antifungal drugs, such as terbinafine cream, ketoconazole cream, etc., if the topical drug is ineffective, oral antifungal drugs, such as itraconazole, ketoconazole and so on. 3. Keratosis pilaris: it is a kind of chronic eczema, there can be dry cracked palms and hard skin performance, you can use glucocorticosteroid treatment, such as hydrocortisone cream, methylprednisolone acetate cream and so on. 4. palmoplantar keratosis: palmoplantar keratosis can have dry cracks and hard skin performance, you can use topical retinoic acid cream, salicylic acid cream, urea cream and so on to soften the keratin, and then use glucocorticoids to improve the therapeutic effect, the serious can be taken orally isotretinoin or Avicenna and so on, but pay attention to retinoic acid drugs preparation for pregnant women and women prohibited during pregnancy. Palm dry cracked hard skin patients, it is recommended to go to the hospital in a timely manner, a clear cause, under the guidance of the doctor to carry out active treatment, do not unauthorized use of medication, to avoid adverse consequences.