The 12-year-old girl’s knee and calf pain may be related to malnutrition, muscle strain, arthritis and other reasons, and can cooperate with the doctor to receive medication, physical and other symptomatic treatment to improve the symptoms. 1. malnutrition: 12-year-old girl knee calf pain pressure pain, may be related to the body lack of calcium, vitamin D and other elements, resulting in bone growth and development affected. Can take calcium complex vitamin D tablets under the guidance of a professional doctor, usually can eat bones, fish, shrimp and other food rich in calcium, vitamin D and other nutrients. 2. Muscle strain: 12-year-old girls may strain their muscles when they exercise or walk. This condition causes pain and bed rest is recommended. Promote local blood circulation and improve pain symptoms through hot compresses and light therapy. 3. Arthritis: Children suffering from juvenile idiopathic arthritis, osteoarthritis and other diseases will induce local inflammatory reaction, causing damage to joint cartilage. Pain caused by this condition can be combined with the doctor to take ibuprofen, naproxen and other non-steroidal anti-inflammatory drugs. Clinically there may be other reasons for 12-year-old girl knee calf pain pressing pain, it is recommended to take the child to the orthopedic department as soon as possible, to clarify the cause of the disease. The above drugs should be used under the guidance of a doctor.