Numbness of the toes can be an early symptom of certain major diseases. Cerebral infarction, amyotrophic lateral sclerosis patients early symptoms is the distal limb numbness, weakness, in addition, lumbar disc herniation, diabetic peripheral neuropathy and other diseases can show similar symptoms, can cause numbness in the toes of the symptoms of a number of diseases, it is recommended to consult a professional doctor. 1. Cerebral infarction, cerebral ischemia: cerebral atherosclerosis and other causes of cerebral ischemia, cerebral infarction can cause numbness in the distal limbs, the patient can be based on the condition of the early acceptance of medication to improve cerebral circulation and surgery to restore the blood supply to the brain tissue treatment. 2. amyotrophic lateral sclerosis: amyotrophic lateral sclerosis patients with early symptoms of the disease that is the distal limb muscle weakness, sensory impairment, patients with numbness in the toes may be the cause of amyotrophic lateral sclerosis, the disease is still a lack of targeted treatment methods. 3. Lumbar disc herniation: the herniated lumbar disc compressing the spinal cord and nerve roots can lead to numbness in the patient’s toes, and the patient can receive lumbar discectomy to relieve the symptoms. 4. Diabetic peripheral neuropathy: patients with a long history of diabetes can develop peripheral neuropathy and peripheral vascular disease, patients can experience numbness in the toes due to reduced blood supply to the distal part of the limbs and nerve degeneration. It is recommended that patients consult a regular hospital in a timely manner to identify the specific causes of numbness in the toes, and receive timely treatment after the diagnosis is clear, so as to avoid deterioration of the condition.