Pneumonia combined with fever, do need to take azithromycin recommended fasting; cephalosporins can be fasting or after meals. At the same time need to pay attention to adverse reactions and contraindications. Pneumonia often appear after fever and other symptoms, for the treatment of pneumonia, the specific use of antibiotics, according to the bacterial culture and other tests to choose sensitive antibiotics. If azithromycin and cephalosporins are confirmed to be necessary, it is recommended that azithromycin be taken more than 1 hour before or 2 hours after meals. Cephalosporins are abundant and need to be taken according to specific drugs. Special populations such as children, patients with impaired liver and kidney function need to follow the doctor’s instructions to adjust the dose of the drug. Alcohol consumption is absolutely prohibited while taking cephalosporins. When taking azithromycin or cephalosporins, if nausea, vomiting, skin rash, transaminase elevation and other adverse reactions occur, it is recommended to stop using the drug and consult a doctor promptly. Azithromycin is contraindicated in cases of drug allergy, presence of impairment of liver function, presence of abnormal liver function, Clostridium difficile-associated diarrhea. Caution should be exercised during pregnancy and lactation. Cephalosporins are usually contraindicated in cases of drug allergy, alcoholism, etc. The specific contraindications depend on the condition. The above drugs need to be used under the guidance of clinicians.