Blistering and bleeding on the lips and mouth may be due to the presence of herpes simplex, mouth ulcers, lipitis and other diseases, which can be treated with medication. 1. Herpes simplex, if invaded by the herpes simplex virus may lead to blistering and bleeding on the lips and mouth, can be treated with antiviral drugs such as acyclovir and valacyclovir under the guidance of a doctor. 2. Mouth ulcers, if there are mouth ulcers, oral mucous membrane breakage, may produce lip blistering and bleeding symptoms, you can use watermelon cream, cidadeine iodine tablets and other drugs to treat. 3. Lipitis, patients with lipitis due to inflammatory stimulation of the lips, may lead to changes in the skin of the lips, so there will be blistering and bleeding symptoms, you can follow the doctor’s instructions to use tacrolimus, pimecrolimus and other drugs. Usually need to observe more personal situation, if found obvious bleeding infection and other symptoms recommend timely medical attention. Under the guidance of the physician to use drugs.