Moderately differentiated carcinoma of the sigmoid colon may or may not require chemotherapy, which needs to be determined according to the staging.
Middle-differentiated adenocarcinoma of the sigmoid colon is staged according to TNM: T1 is tumors invading the submucosa, T2 is tumors invading the muscular layer of the mucosa, T3 is tumors penetrating the muscular layer to reach the subplasma membrane or invading the paracolorectal tissues without peritoneal coverage, and T4 is tumors penetrating the dirty peritoneum or invading other organs or tissues.
N0 is the tumor without lymph node metastasis, N1 is the tumor with 1~3 lymph nodes metastasis, and N2 is the tumor with more than 4 lymph nodes metastasis.M0 is the tumor without distant metastasis, and M1 is the tumor with distant metastasis.
Stage I is the tumor with T1~T2, N0 and M0; Stage II is the tumor with T3~T4, N0 and M0; Stage III is the tumor with T1~T4, N1~N2, and M0; Stage IV is the tumor with T1~T4, N0~N2, and M1.
Usually stage I and II can be resected by radical surgery, and those without risk factors do not need chemotherapy after surgery. Stage III and above need to be treated by surgery plus chemotherapy, and for some patients who have lost the chance of surgery, the treatment is mainly through chemotherapy, which can also be supplemented with targeted therapy and other methods of treatment.
Specific treatments need to be determined with the help of doctors and according to the patient’s condition. If diagnosed with moderately differentiated cancer of the sigmoid colon, please consult the doctor in time and follow the doctor’s instructions for treatment.