Diabetic nephropathy is the most common complication of diabetes mellitus and one of the leading causes of death in diabetic patients. Extra-renal organ damage occurs earlier, more frequently and more severely in patients with end-stage diabetic nephropathy than in uremic patients with other primary conditions that are not diabetes. For example, cardiovascular system complications (cardiovascular disease is the leading cause of death in uremic patients), peripheral vascular disease, peripheral and autonomic neuropathy, retinopathy and gastrointestinal disease, etc. The above complications are the most important causes of long-term survival and quality of life for patients, and the complications progress at an increasingly rapid rate. For example, a study found that the period of 1 to 2 years before the start of dialysis is the fastest progression of diabetic retinopathy. Early initiation of dialysis treatment in patients with diabetic nephropathy is expected to mitigate the progression of retinopathy. Early dialysis treatment is also an effective measure to mitigate damage to other important extra-renal organs, and thus dialysis treatment should be started earlier than in patients with non-diabetic nephropathy, whether on peritoneal dialysis or hemodialysis. If the patient has obvious symptoms of uremia, heart failure, uncontrollable high volume, retinopathy, etc., it is advisable to start dialysis treatment earlier in order to alleviate the damage of extra-renal organs even, prolong the life of the patient and improve the quality of life.