Long-term consumption of estradiol in women may increase the risk of cancer in breast tissue, endometrial tissue, and increase the risk of blood clots. When women take estradiol for a long period of time especially during perimenopause, menopause and postmenopause, estradiol can stimulate women’s estrogen-sensitive reproductive organs, such as endometrial tissues and breast tissues, and abnormal proliferation of endometrium or breast, with the possibility of endometrial lesions, breast tissue lesions, and even increase the risk of endometrial cancer and breast cancer. In addition, long-term estradiol can also elevate the risk of blood clots, lead to endocrine disorders, and cause increased burden on the liver and kidneys. Therefore, women taking estradiol for a long period of time need to have regular blood tests, coagulation function, liver and kidney function, breast ultrasound, uterine ultrasound. And they need to use medication reasonably under doctor’s guidance to reduce the risk of medication.