Wash off the Metronidazole Gel in about 12 hours after application, and if you need to continue the treatment, wash it off and then continue to smear the medicine. Metronidazole gel can sterilize, anti-inflammatory, anti-itching, mainly used for inflammation of skin follicular tissue caused by inflammatory infections, impetigo, acne, rosacea and other treatments. Occasionally, skin burning, dryness, tingling and other allergic reactions. If you suffer from skin acne, rosacea, etc., you need to use sulfur soap to clean the facial skin in the morning and evening every day, and then apply metronidazole gel to the affected area, and in the middle of the time, you do not need to wash off the metronidazole gel, and the drug is continuously retained in the affected area, which can improve the therapeutic effect. Be careful not to get the drug into the nose, eyes and mouth to avoid adverse reactions, and it is contraindicated for breastfeeding women as well as pregnant women. Metronidazole gel needs to be used under the guidance of a doctor, not self-medication to avoid adverse reactions. If you have any other questions, it is recommended to consult a professional doctor for guidance.