Staying up late headache is mostly caused by chronic ischemia and hypoxia of brain tissue leading to vasospasm, but it may also be caused by tension headache, ophthalmogenic headache and neurological headache and other factors. Stay up late when the brain cells are overworked without sufficient rest, brain tissue chronic ischemia and hypoxia caused by cerebral vasospasm and lead to headache symptoms. This is the most important reason for staying up all night with headaches. Other causes of late-night headaches include tension headaches caused by neck muscle strain, ocular headaches caused by prolonged eye use, and neurological headaches caused by endocrine disorders. Prolonged stay up late with persistent headache symptoms, not except for exertion and stay up late caused by intracranial organic lesions may be recommended that the patient in a timely manner to the regular hospital to clarify the cause of the disease, so as not to delay the condition.