Toothache can be caused by periodontitis, endodontitis, apical periodontitis, etc. Usually, the most effective ways to relieve toothache are medication, surgery, root canal treatment, etc. There is no such thing as the most effective way to relieve toothache. There is no such thing as the most effective way to relieve toothache. 1. Periodontitis: Usually patients can take systematic periodontal treatment to eliminate inflammation, prevent the development of the disease and restore the function of periodontal tissues. Generally food blockage caused by periodontitis, the need for orthodontic treatment and pay attention to oral hygiene. 2. Pulpitis: Generally, different types of pulpitis have different treatment methods, such as reproducible pulpitis, can be used to protect the pulp of the treatment methods, such as pulp capping. For irreducible pulpitis, root canal treatment is needed. 3. Periapical inflammation: Usually, periapical inflammation refers to the inflammation of periapical tissues of the tooth, and the main symptoms are occlusal and percussive pain, etc. Patients can have root canal treatment to clean up the periapical tissues. Patients can undergo root canal treatment to clean up the infected pulpal tissue and root canal anti-inflammation, and finally crown restoration. Patients can also take oral medications such as metronidazole or tinidazole under the direction of the doctor to relieve the symptoms of toothache while undergoing root canal treatment. There are many other causes of toothache, and patients are advised to seek timely medical consultation and different treatments according to different causes. The above medications need to be used regularly under the guidance of a doctor.