Patients with advanced lung adenocarcinoma had better not to smoke, the five-year survival rate of advanced lung cancer is about 5%. Smoking is not recommended for patients with advanced lung adenocarcinoma because it may lead to further development of the disease, deterioration and other situations, and reduce the survival rate. Lung adenocarcinoma is a kind of malignant tumor originated from bronchial epithelial mucosal epithelium and mucous glands, its development is related to smoking, heredity, atmospheric pollution and other factors. Paper cigarette contains more than 10 kinds of carcinogenic substances such as benzo(a)pyrene, nicotine, nitrosamines, trace arsenic and so on, which can aggravate the condition of patients with advanced lung adenocarcinoma. In terms of treatment, patients with advanced lung adenocarcinoma can be treated by radiotherapy and immunotherapy for those who are negative for the driver gene; for patients with advanced lung adenocarcinoma who are positive for the driver gene, they can be treated with targeted drugs, supplemented by immunotherapy, etc., and the survival period of the patients can often reach 2-5 years, or even longer. If diagnosed with advanced lung adenocarcinoma, please quit smoking and follow the doctor’s instructions for treatment.