Botox just sounds like a scary name. And it is true, botulinum toxin is a highly toxic agent, a very small dose can cause death, so why can we apply it safely? Why is its application in cosmetic surgery in full swing and popular all over the world? This is because we apply the concentration and dose is far below its safety limit, so it is very safe. In fact, its application has a very interesting story. In 1986, a Canadian ophthalmologist named Joan Carasso was applying it. In 1986, a Canadian ophthalmologist named Joan Carasso was applying Botulinum toxin type A to treat eye spasms, when she accidentally discovered that this neurotoxic drug, which is used to paralyze the muscles, could make the wrinkles of the patient’s eyes disappear. She told her husband, a professor of dermatology, about the surprise. Later, the couple began to cooperate on this topic, and eventually introduced Botulinum toxin type A into the field of skin wrinkle removal, and published the first relevant report in 1990, triggering the so-called “Botox revolution” in the history of beauty. After the United Kingdom and the United States, China was the third country to produce this cosmetic product on its own, and began to use it in 1999. So what is the principle of Botox to remove wrinkles? The reason why Botox has the effect of removing wrinkles is that it can inhibit the release of acetylcholine from the presynaptic membrane of the peripheral motor nerve endings, blocking the transmission of information between the nerves and the muscles, thus causing flaccid paralysis of the muscles. Our human wrinkles are mostly the result of facial expression muscles, and Botox paralyzes the muscles so that the muscles do not have the ability to pull and stretch or eliminate the wrinkles. Botulinum toxin injection wrinkle removal has the characteristics of small trauma, quick effect, convenient operation, inexpensive, does not affect the work and so on. Compared with traditional chemical peeling, facelift, collagen injection, fat charging or small incision wrinkle removal, it only requires a certain dose of botulinum toxin to be injected into the surgical area, and the whole process only takes a few minutes and is almost painless. The downside is that Botox wrinkle reduction is time-sensitive. After injecting Botox into the wrinkles, the wrinkles will gradually flatten out after 1 to 7 days. The maintenance of the wrinkle reduction effect is usually 3 months to 6 months. In order to maintain long-term cosmetic effects, you need to inject 2 to 3 times a year. It is understood that using Botox to remove wrinkles, general crow’s feet, forehead lines, frown lines, nose lines and neck wrinkles can be removed. However, it is best suited for early, less visible wrinkles. If the patient’s wrinkles are deep, it can be combined with the application of tissue fillers (such as hyaluronic acid, etc.); if the skin is very loose, traditional skin lifting procedures can be considered. So, Botox wrinkle reduction is not a panacea, but its definitive results and minimal complications make its application the number one cosmetic surgery procedure. It is worth noting that Botox for wrinkles cannot be used by pregnant women, lactating women, patients with myasthenia gravis, allergy sufferers, ptosis sufferers and patients with internal diseases such as heart, liver, lungs and kidneys. A serendipitous discovery, casting the inevitable in the history of beauty.