Over-indulgence will not cause kidney failure. Over-indulgence, in Chinese medicine, is called kidney deficiency, which is not an organ but a whole, mainly referring to sexual function problems. Long-term kidney deficiency can lead to sexual dysfunction, impotence, premature ejaculation, and decreased libido. And kidney failure refers to a group of syndromes in which kidney dysfunction and decreased glomerular filtration rate cause systemic disorders of water-electrolyte acid-base balance and endocrine metabolic disorders. Patients with kidney failure can cause gonadal atrophy, causing sexual dysfunction. Once kidney failure occurs, there is no specific drug treatment in medicine. Once the symptoms of uremia, nausea, vomiting, loss of appetite, heart failure, generalized edema, and poor diuretic effect, renal replacement therapy, hemodialysis or peritoneal dialysis treatment can be performed.