Hepatocellular carcinoma is currently graded by several indicators, such as cell morphology, arrangement, nucleoplasmic ratio, nuclear schizophrenia, etc. At present, it is categorized into grade IV. Currently, it is divided into grade IV. The lower the grade, the better the differentiation of cancer cells; the higher the grade, the worse the differentiation of cancer cells. Among them, grade I is considered to be highly differentiated pathologically, grades II and III are considered to be moderately differentiated, and grade IV is considered to be poorly differentiated. Clinically, according to the grading of hepatocellular carcinoma, combined with other pathological tests, certain judgment can be made on the prognosis of hepatocellular carcinoma. Grade I is mainly characterized by cancer cells with morphology similar to that of normal hepatocytes, which are arranged in the form of strips, with eosinophilic cytoplasm, regular size of nuclei, and very rare nuclear schizophrenia; Grade II is mainly characterized by mildly altered morphology of cancer cells, which are arranged in the form of strips or nests, with obvious increase in the ratio of nuclei to plasma and increase in the number of nuclear schizophrenia; Grade III refers to the obvious deformation of the cancer cells, which are arranged in the form of nests, and the ratio of nuclei to plasma continues to increase, with unequal nuclei sizes and irregular staining, and the number of nuclear schizophrenia is also common. Grade III refers to the cancer cells are obviously deformed, in a nest-like arrangement, the nucleoplasma ratio continues to increase, the nuclei are of unequal sizes, the staining is also irregular, nuclear schizophrenia is common, and sometimes giant cancer cells can be seen; grade IV refers to the cancer cells are obviously heterogeneous, and spindle cells and multinucleated giant cells can be seen, the cytoplasm is small but the nuclear staining is deep, the nuclear schizophrenia is common, and the cellular arrangement is disturbed.