The causes of dark spots on cheeks include age spots, freckles, pigmented moles, chloasma, etc. Creams for treatment include vitamin E cream, trichloroacetic acid cream, retinoic acid cream, and 2% to 5% hydroquinone cream. 1. Age spots: In case of age spots, physical therapy and surgery are usually the main treatment, and medication is less frequently used. 2. Freckles: If the dark spots on the cheeks are freckles, cosmetic lasers such as photorejuvenation are commonly used, and medication is seldom used to avoid the consequences of hyperpigmentation and scarring. 3. Pigmented nevus: If the dark spot is caused by pigmented nevus, it usually cannot be treated with medication, but commonly used methods such as laser or surgical excision. 4. Melasma: If the melasma is caused by many factors, 2%~5% hydroquinone cream can be applied to get rid of the dark spots. Please consult doctor in time for the phenomenon of dark spots on cheeks, and the above medicines must be used reasonably according to doctor’s prescription.