Gastric low-differentiated cancer is a kind of gastric cancer, which can be divided into high differentiation, middle differentiation and low differentiation according to the differentiation of cells. Hypo-differentiated represents that gastric cancer cells are less differentiated and have higher differentiation potential. Stage III gastric poorly differentiated cancer tumor is more malignant, grows faster and is prone to metastasis. The treatments for stage III gastric poorly differentiated cancer include surgery and chemotherapy, among which radical gastric cancer surgery is the most promising method for radical treatment at present. For progressive gastric poorly differentiated cancer, if there is no distant metastasis, surgery should be performed as far as possible. For patients who already have distant metastasis, in order to keep the digestive tract unobstructed and improve nutrition, gastric resection is usually not done, only palliative surgery. Patients with stage III gastric low-differentiated cancer should also be treated with chemotherapy, such as 5-FU, mitomycin and vincristine. For patients with advanced gastric cancer with lymph node metastasis or progressive gastric poorly differentiated cancer, as well as patients with large local tumor volume, which is difficult to be resected, they can be treated with adjuvant radiotherapy, chemotherapy (5-FU, mitomycin, vincristine, etc.) to reduce the tumor and improve the success rate of surgical treatment. Patients with gastric low-differentiated cancer stage III are recommended to cooperate actively according to the doctor’s instruction, keep happy during the treatment and eat less spicy and stimulating food, which can be conducive to the recovery of the disease.