Barrett’s esophagus refers to a precancerous condition in which the squamous epithelium of the lower esophagus is covered by columnar epithelium. Barrett’s esophagus is a pathologic alteration of the squamous epithelium on the inner surface of the lower esophagus, where normal tissue is replaced by tissue similar to the inner surface of the gastrointestinal tract, for example. The exact cause of the disease is not clear, but it may have a strong relationship with age factors, gender factors, race, obesity, etc. It often presents with symptoms such as heartburn, acid reflux, heartburn, etc. Some patients also present with symptoms such as chest pain, dysphagia, vomiting of blood, and blood in the stool. Barrett’s esophagus patients should pay attention to quit smoking and drinking, develop a good lifestyle, and with oral omeprazole, rabeprazole, itopride, mosapride, etc., to alleviate the symptoms and promote the recovery of the condition, and some patients with serious conditions need to take endoscopic surgical treatment or surgical treatment. Patients with suspected symptoms of Barrett’s esophagus must go to the hospital in a timely manner, cooperate with the doctor to take the relevant examinations and treatments, to avoid further progression of the condition, and medications should be used in accordance with the doctor’s instructions.