Chronic rejection occurs 6-12 months after kidney transplantation and is mainly manifested in the following aspects: first, progressive transplanted kidney function decreases, urine volume gradually decreases, abdominal distension, painful sensation when touching the allograft kidney in the groin, and general weakness, facial swelling, pale eyelids, dirty face, endogenous creatinine clearance rate in the body decreases significantly, blood creatinine increases, and after urination will After urination, hematuria and proteinuria will appear in different degrees, and in severe cases, all the functions of the transplanted kidney will be completely lost. Chronic rejection will persist after kidney transplantation, but the time and severity of the rejection will vary according to the immune response and physical quality of the body. When chronic rejection after kidney transplantation occurs, go to the hospital for blood tests in time to clarify the severity of the disease, and it is recommended to carry out conditioning under the guidance of the surgeon, which can slow down the development of the disease.