Diabetic nephropathy is one of the common chronic microvascular complications of diabetes and is an important cause of death in diabetes. In type 2 diabetes, its incidence is about 15%-60%. Due to the lack of specific treatment in modern medicine, once patients develop persistent proteinuria, the disease will often continue to progress until nephrosis and uremia. Therefore, early detection and treatment of diabetic nephropathy is of great significance. Diabetic nephropathy, like other chronic complications, is complex and multifactorial. These factors may include poor glycemic control, genetic factors, excessive protein intake, hypertension, excessive secretion of growth hormone and glucagon, abnormal lipid metabolism, hyperplatelet function, renal hemodynamic abnormalities, structural abnormalities, and smoking. The pathological changes in early diabetic nephropathy manifest as an increase in kidney volume, with initial involvement of the thylakoid membrane. The underlying pathology is an increase in basement membrane-like material and involvement of thylakoid cells, along with capillary basement membrane thickening. Glomerular changes are often clinically classified into three types: nodular glomerulosclerosis, diffuse glomerulosclerosis, and exudative lesions. The clinical manifestations of diabetic nephropathy include proteinuria, swelling, hypertension, decreased renal function and altered glomerular filtration rate. It is currently divided into five stages: stage I with hypertrophy and hyperfunction of the kidney, also known as the glomerular hyperfiltration stage; stage II with the onset of structural glomerular damage and microalbuminuria on exercise tests; stage III clinically characterized by persistent microalbuminuria with a substantial increase on exercise tests, and blood pressure that starts as normal and then gradually increases; stage IV, the stage of clinically significant diabetic nephropathy with persistent proteinuria, hypertension, and The first three stages are collectively called early diabetic nephropathy. The first three stages are collectively referred to as early diabetic nephropathy, which has a high reversal rate when treated aggressively with a combination of Chinese and Western medicine. There is no uniform standard for the diagnosis of this disease. Commonly used examination methods are: 1, kidney biopsy: clinical research shows that even in diabetic patients with normal urinalysis, the kidney may already have histological changes, therefore, kidney biopsy has definite early diagnostic significance, but because it is an invasive test, it is not easily accepted by patients; 2, urine protein measurement: increased urine protein, which is one of the clinical features of diabetic nephropathy, is also the main diagnostic basis of the disease. Early diabetic nephropathy can be diagnosed if there are two consecutive urinary albumin excretion rates between 30-300mg/24 hours in urine examination within six months and other possible causes of increased urinary protein are excluded, such as ketoacidosis, urinary tract infection, exercise, primary hypertension, heart failure, etc. 3.Increased glomerular filtration rate and increased kidney volume: Glomerular hyperfiltration is the only basis for the diagnosis of stage I diabetic nephropathy. However, in the early stage of diabetes, even in the abnormal glucose tolerance period, there is hyperfiltration and increased kidney volume, so the value of this test is very controversial; 4. Other early diagnostic indicators: such as increased immunoglobulin in urine, which can reflect the degree of damage to the early charge barrier; elevated urinary transferrin, whose significance is similar to that of albumin; many urinary enzymes are also sensitive indicators for early diagnosis, etc. There is no special treatment for diabetic nephropathy. At present, western medical treatment is mainly for diabetes, blood sugar control, blood pressure control and diet therapy. On the basis of the above treatment, I formulated my own kidney formula to treat diabetic nephropathy, commonly used drugs such as: princeton ginseng, astragalus, poria, atractylodes, Chuan break, eucommia, dogwood, cow knee, angelica, danshen, chuanxiong, snake tongue grass, etc. The formula has the effect of benefiting the kidney and activating blood. If edema is obvious, add Poria cocos, Zelenia laxiflora, Rhizoma macrocephalus, and Motherwort; if yin is deficient and thirsty, add Rhizoma smallpox, Rhizoma yucca, and fresh rhizome; if stool is dry, add Citrus aurantium, Rhizoma rhizoma, and Peach kernel; if dampness and heat are heavy, add Phellodendron, Zhi Mu, and Bamboo rhizome; if dizziness and blood pressure are high, add Xia Ku Cao, Semen cassia, and Tribulus terrestris. Satisfactory results, welcome the majority of diabetic nephropathy patients to come to the doctor.