The most common disease in gastroenterology is duodenal bulbous ulcer, the main manifestation of which is nocturnal pain, fasting pain or even waking up with pain. The main manifestation is that the pain is aggravated in the state of hunger, and the symptoms will be gradually relieved after eating, so the pain will be obviously aggravated in the night time on an empty stomach, and the symptoms will be insignificant or not felt during the daytime after a normal diet. It is recommended that the patient go to the hospital to improve the electronic gastroscopy, carbon 14 Helicobacter pylori test, 90%-100% of patients with duodenal bulb ulcers are combined with Helicobacter pylori infection. In addition, Helicobacter pylori is also a high-risk factor leading to gastric cancer, it is recommended that patients with this symptom should consult the doctor as soon as possible, check and make a clear diagnosis, and they can carry out regular quadruple bactericidal as well as anti-ulcer treatment, and the drugs for anti-ulcer treatment are mainly proton pump inhibitors, and the representative drugs are omeprazole, etc., and the course of treatment can be finished in 2-4 weeks.