The normal range of 24-hour urine protein quantification for a normal person is 0 to 150mg. 180mg out of the normal range may be caused by physiological or pathological factors, which are generally not considered serious. Physiological factors such as strenuous exercise, fever, stress, renal tubular spasm can lead to physiologic proteinuria. But this kind of proteinuria is transient, usually lasts for a short period of time, when the triggering factors are removed, it will soon return to normal, usually not serious, just need regular review. Pathologic proteinuria is usually caused by various kidney diseases, such as glomerulonephritis, nephrotic syndrome, interstitial nephritis and so on. At this time, further examination is needed to clarify the diagnosis, in addition, combined with imaging tests, if necessary, feasible renal puncture biopsy, in order to clarify the cause of the disease. Whether the condition is serious or not at this time is related to the type of disease and personal situation. When proteinuria occurs, it is necessary to go to the hospital for a comprehensive examination to clarify the cause of the disease and then follow the doctor’s instructions to carry out regular treatment in order to avoid delaying the condition.