Cefixime resistance does not necessarily lead to lifelong resistance, cephalosporin resistance can generally be recovered, but the exact time is not yet clear. Resistance to cefixime is generally due to long-term irregularity or abuse of drugs, such as randomly increasing or decreasing the amount of medication, intermittent medication, abuse, etc., may cause the bacteria to develop resistance, the emergence of resistance indicates that the use of drugs in the future period of time may not be able to achieve a better therapeutic effect, but it is not necessarily a lifelong. When using antibiotic drugs for treatment, must be under the guidance of the doctor to follow the doctor’s instructions, not self-medication or unauthorized discontinuation of drugs.