Grainy stools may be caused by constipation, gastrointestinal dysfunction, colorectal cancer, etc. Depending on the cause, volumetric laxative such as polycarbophil calcium, lubricant such as paraffin oil, endoscopic submucosal dissection, etc. may be adopted for treatment. 1. Constipation: the treatment is mainly to promote defecation, using volumetric laxatives such as polycarbophil calcium, osmotic laxatives such as polyethylene glycol, etc. to treat. 2. Gastrointestinal dysfunction: it can be treated with lubricants such as paraffin oil, magnesium oxide, etc., gastrointestinal stimulants such as domperidone, etc., and anticholinergic drugs such as atropine. 3. Colorectal cancer: endoscopic submucosal dissection, traditional open surgery, regional lymph node dissection and other surgical treatments can be adopted. It is recommended to consult the doctor in time and use medicines under the doctor’s guidance, and not to blindly use medicines by oneself to avoid adverse effects.