The main clinical symptoms of Parkinson’s disease are as follows: 1. Tremor: the distal part of the limb is the focus, usually starting with one hand, and as the disease progresses, the opposite limb, mouth, lips, jaw and tongue can also appear. The tremor appears as a “pill-rolling” movement of the hand. The tremor is characterized by occurring at rest, decreasing with movement, disappearing after sleep, and worsening with emotional stress. Severe tremor may cause the patient to lose the ability to write. 2.Muscle ankylosis: presents with extrapyramidal hypertonia. Characteristically, the increased muscle tone is often found in the muscles of the extremities, neck and face. The resistance to extension and flexion of the joints is relatively uniform, called “leadpipe-like ankylosis”; if the patient is combined with tremor, it is “gear-like tremor”; the facial expression is dull and rarely transient, called “mask face If the patient has a combination of tremor, it is called “cogwheel tremor”; facial expression is dull and rarely transient, called “mask face”; swallowing muscle ankylosis, manifested by swallowing difficulty and salivation; speech-related muscle ankylosis, manifested by monotonous and slow speech, small voice and repetition. 3. Decreased movement: Patients have various movements, such as dressing, buttoning, brushing teeth, washing face, tying shoelaces, etc., are slow and reduced, and often sit still. The writing is too small, often getting smaller and smaller, called “writing too small sign”. When walking, the distance between the two steps is reduced, and the steps are small. Speech is low, monotonous language, later there may be swallowing difficulties, coughing and choking when eating, and even late need to put down the nasal feeding tube. 4, abnormal posture: because of the limbs, trunk and neck muscles straight, standing head and neck and trunk forward, knee joints slightly flexed; upper limbs with (or with) movement disappeared, the patient walked faster and faster, a forward posture and can not suddenly stop, called “panic gait”. Some patients in a certain stage of the disease, due to the lower limb extension, flexion muscle tone is abnormal, can not walk forward normally, but can walk backwards, think it is easier. 5.Other: There may be difficulty in urination and defecation, excessive sweating, seborrhea and upright hypotension and other symptoms of vegetative nervous disorder. But the disease does not cause urinary and fecal incontinence. There may also be depressed mood, low libido, mostly normal intellectual and emotional responses, but occasionally dementia or mental abnormalities. 6.Progression and fluctuation: Overall, the disease is progressing, but the speed from the appearance of symptoms to cause dysfunction varies greatly from patient to patient. Some patients progress rapidly and may lose motor function within 5 years of the disease. However, most patients have a slow disease course, and a few patients can still live on their own 10 to 20 years after the onset of symptoms. Climate has a certain influence on patients’ motor impairment, for example, in dry, cool and high pressure seasons, patients will feel their condition improve. In the case of excessive fatigue, mental stress, systemic infection, and the relative increase of anions in the air due to hot and humid weather, the condition will worsen, and even induce abnormalities related to movement, such as “on-off”, “freezing”, and “freezing”. “freezing” and other phenomena. These phenomena are most often seen in patients with more severe disease or in the course of drug therapy.