After an unsuccessful IVF treatment, you may feel lost and at the same time enter into a “problem solving” mindset, “What should I do next? is a question that all people naturally ask. Let’s first look at the reasons for the failure of the first IVF, and maybe you will find your own answer to the question “what should I do next? Reason 1: Embryo development potential. A good embryo is inextricably linked to the quality of the egg, the quality of the sperm, and the normal replication and division of the embryo itself, and problems with any of these three may affect the final outcome. This requires the doctor and embryologist to carefully analyze the details of the ovulation process, whether the eggs are of the right morphology, size, structure and other indicators after retrieval, and how they are scored. These questions will actually be marked in your file by the embryologist. As an example of one of these issues: the formation of a quality embryo can be affected by an impaired sperm-egg union, which can be due to a problem with the sperm’s ability to penetrate the egg, or the egg zona pellucida is too thick for the sperm to penetrate, a condition that can only be detected under the observation of the embryologist in the laboratory and is not visible before the IVF, because during natural conception it is not possible to put the egg under microscope and measure them under the microscope to see if they pass indicators such as the thickness of the zona pellucida, which can only be done after egg retrieval. Reason 2: Endometrial problems. Considering the implantation aspect, there is also the problem of the endometrium. Some endometrium is a beautiful type A when ultrasound is done, but when hysteroscopy is done to visualize the manifestation of endometritis, this insidious one is also not easily detected. In fact there are many possible causes that need to be analyzed and judged by the physician. Reason 3: Psychological factors. Psychological adjustment should not be neglected. Women undergoing IVF bear a lot of pressure and should learn to self-regulate during the treatment process, and the family should also work together with her in a concerted effort to actively face the problem and solve it. If necessary, seek adjustment from a psychologist. Reason 4: Pure probability event. The success rate of IVF varies from 40-60%, and the success rate varies from person to person, so the reason for not succeeding is sometimes “no reason” and indeed “a bit capricious”, which is perhaps what our predecessors said “Fate has not arrived”, why not pack up and start again? Maybe success is waiting for you at the next stop. Reason 5: Other special reasons. There are also some “mysterious” reasons, such as abnormal blood clotting, immune factors, metabolic problems, vitamin deficiencies (for example, you always do the sunscreen so perfectly, the body vitamin D levels may be ultra-low), and so on, with the development of reproductive medicine, these problems are gradually unearthed by medical scientists. Failure is the mother of success, in fact there are many reasons for infertility, some problems are not found before doing IVF, while some problems can only develop during the process of IVF. It is important to actively seek help from your doctor to analyze the reasons for failure and to know which of the above situations you belong to. If it is a probable event and it is really anywhere, then feel free to fight again; if you are able to find the cause, you need to listen to your doctor to fix the problems found and then proceed to the second cycle. In short, the discovery of the problem is a good thing, is the problem will have the appropriate solution, do not be afraid, positive face.