Leukoaraiosis is generally not self-healing. Leukoaraiosis belongs to one kind of systemic vasculitis, which is a systemic autoimmune disease with multi-system and multi-organ involvement, and the clinical manifestations are recurrent oral ulcers, ocular uveitis, genital ulcers and other symptoms, which generally will not be cured by themselves. Patients can take immune-regulating drugs or immunosuppressants to achieve relief, common drugs are methotrexate and methylprednisolone tablets. Most patients with leukoaraiosis have a long course of the disease and are prone to recurrent episodes, and the severity of the symptoms and the duration of the episodes vary greatly. Patients with leukoaraiosis should pay attention to avoiding spicy and stimulating food in daily life, exercise properly, improve immunity, and keep a happy mood. It is recommended that patients with leukoaraiosis should go to the hospital in time and receive symptomatic treatment under the doctor’s guidance to avoid delaying their condition.