The grading of splenomegaly is related to the disease and can be categorized into mild splenomegaly, moderate splenomegaly and extreme splenomegaly. 1. Mild splenomegaly: if the lower edge of the spleen needs to be less than 2cm below the rib margin during deep inhalation, then it is mild splenomegaly. Mild splenomegaly may occur when the patient suffers from cirrhosis, portal hypertension, early schistosomiasis, and systemic lupus erythematosus. 2. Moderate splenomegaly: when the patient takes a deep breath, the enlargement of the spleen is larger than 2cm below the margin and does not reach the umbilicus. It is possible that the patient suffers from splenic amyloidosis, acute granulocytic leukemia, malignant lymphoma and other diseases that lead to moderate splenomegaly. 3. Extreme splenomegaly: If the lower margin exceeds the level of the umbilicus, extreme splenomegaly or megasplenism can be recognized. Patients with advanced schistosomiasis, thalassemia, chronic granulocytic leukemia, Gosheimer’s disease, etc. may have a giant spleen. The current treatment for enlarged spleen is usually to determine the cause of the enlarged spleen and then to tailor the treatment to the cause. In some patients, when the splenomegaly is severe and there are no contraindications, it may be necessary to undergo splenectomy through surgery in a timely manner to achieve relief of the condition.