Taking ibuprofen for urethral pain is not very useful. Ibuprofen is mainly used for chronic dull pain such as toothache, headache, shoulder pain, muscle pain, arthralgia, neuralgia, and primary dysmenorrhea. After oral intake, ibuprofen will block the body’s release of the pain-causing substance, prostaglandin E2, at the site of pain, thus exerting a pain-relieving effect. The common causes of urethral pain include urinary tract infections and urethral stones. Urinary tract infections are often caused by bacteria, fungi, mycoplasma, chlamydia, etc., and need to be treated with medications that can kill these microorganisms, while ibuprofen can not kill them, so ibuprofen can not be used for the treatment of urethral pain, and may only play a temporary relief. Urethral pain caused by urinary stones is mostly spasmodic pain in the smooth muscles of the urethra, and ibuprofen does not have an effect on smooth muscle pain. In addition, there are many other causes of urethral pain, such as genital herpes, tumors, pelvic floor muscle tension, etc., and taking ibuprofen does not have a significant pain-relieving effect. In summary, urethral pain is just a symptom of the disease, even if taking ibuprofen works, it is only a temporary relief of pain, and can not completely treat the disease. If the cause of the disease still exists, the pain will persist or recur. Therefore, when urethral pain occurs, it is recommended to go to the urology department or nephrology department of the hospital in time.