Infection with Burkholderia cepacia is more serious and has a high mortality rate if complicated by sepsis. Burkholderia cepacia is a non-fermenting bacterium that is the causative agent of hospital-acquired infections and can also cause community-acquired infections. Its main symptoms manifest as bacteremia, urinary tract infections, and septic arthritis, and it can also cause cystic fibrosis of the human lung. The lesions can lead to more severe endocarditis, resulting in hemodynamic disturbances, occurring in the aortic and mitral valves, causing aortic and mitral valve closure insufficiency or stenosis, etc., and can also cause systemic febrile symptoms. It can also cause pneumonia, wound infection, ocular conjunctivitis, etc. The most common complication is sepsis. When the flora proliferates in the blood, it can cause abscesses in the internal organs and finally death due to sepsis. It is important to take precautions in the hospital by strengthening isolation, hand hygiene, and environmental disinfection. If Burkholderia cepacia onionis infection is suspected, sputum specimens should be sent for examination and anti-infective treatment with sensitive drugs.