Waking up tired and fatigue may be caused by improper sleeping position, lack of sleep and other physiological factors, generally do not need to take special treatment; may also be caused by anemia, hypokalemia and other diseases, need to be treated for the cause. 1. Physiological factors: improper sleeping position, lack of sleep, and strenuous exercise before bedtime may lead to generalized weakness and fatigue after waking up. If there are no other uncomfortable symptoms, it is a normal phenomenon, no need to take special treatment. Sleeping should not be too high or too low pillow, to ensure sufficient rest time, can be relieved. 2. Pathological factors (1) anemia: waking up weak and tired may also be due to anemia, patients can take oral iron dextrose, ferrous gluconate and other organic iron. Most of the patients can improve their symptoms after medication. (2) Hypokalemia: waking up with general weakness and fatigue is also considered to be caused by hypokalemia. Patients can take potassium chloride, potassium citrate and other potassium agents orally as prescribed by doctor. There are many reasons for waking up with general weakness and fatigue, patients are advised to go to regular hospitals to find out the cause of the disease and follow the doctor’s instructions.