After the blockage of cardia in the advanced stage of gastric cancer, it can be healed by palliative surgery, radiotherapy, chemotherapy, targeted therapy and interventional therapy. It is necessary to follow the doctor’s prescription to use medicines. 1. Palliative surgery: For advanced gastric cancer with cardia blockage, if the patient can tolerate it, palliative surgery can be performed to relieve the obstruction symptoms, such as gastric palliative resection, gastrojejunal anastomosis short-circuit surgery and so on. 2. Radiotherapy: the use of high-energy rays to release energy to kill tumor cells can achieve the purpose of relieving obstruction, thus improving the quality of life of patients. 3. Chemotherapy: it can be treated by applying chemotherapeutic drugs, commonly used drugs are 5-fluorouracil, capecitabine, etc. In order to achieve better curative effect, it can also be combined with radiotherapy. 4. Targeted therapy: it is a more accurate therapy with less side effects, commonly used drugs include trastuzumab, apatinib, and so on. 5. Interventional therapy: X-ray-guided stent implantation can be used to relieve the symptoms of obstruction and improve the quality of life of patients.