After thyroid puncture, if it is clearly malignant, it is recommended that the procedure be completed as soon as possible, but the exact time should be determined under the supervision of the doctor in the context of the individual’s situation. There is usually no specific time limit. Fine needle aspiration biopsy of the thyroid is a traditional minimally invasive diagnostic technique that can identify the nature of thyroid nodules prior to surgery, providing the basis for individualized and precise treatment of thyroid disease, and is the key to decision-making in thyroid diagnosis and treatment. If thyroid puncture has been done and the tissue is clearly malignant, it is recommended to arrange for surgery as early as possible if the physical condition permits, but there is no accurate clinical data on how long it will take to perform the surgery, which depends on the individual’s situation. If other abnormalities are found during the puncture procedure or other problems affecting the surgery exist, it is usually recommended to deal with the abnormal reaction first and consider the surgery after the body has returned to normal, and the surgery may be delayed. It is recommended that the thyroid puncture biopsy be performed in a regular hospital, and that you seek medical attention if you become unwell after the test.