Walking on cotton feeling in the feet can be caused by many reasons, clinically it is most commonly caused by elevated blood pressure, patients will have dizziness and head swelling in addition to the performance of walking on cotton feeling. The most common cause of the feeling of stepping on cotton in the feet should also be considered to be caused by deep sensory disorders, and there are many reasons for this, which are clinically more common in peripheral neuropathy. The common ones are peripheral neuropathy, such as peripheral neuritis, metabolic diseases, alcoholism leading to peripheral nerve injury, and posterior spinal cord lesions, such as spinal consumption and subacute joint degeneration of the spinal cord. Cervical spondylosis and lumbar disc herniation of the spinal cord can lead to deep sensory impairment, which is manifested by a feeling of walking on cotton, and should be accompanied by other manifestations of the disease. In cerebrovascular diseases, the most common cause of the sensory impairment of deep and superficial sensation of stepping on cotton is parietal lesions, such as infarction of the parietal lobe or the occurrence of brain tumors in the parietal area.