Numbness of hands and feet may be a physiological condition, or it may be caused by peripheral nerve injury, stroke, etc. Oral vitamin B1, methylcobalamin, aspirin, atorvastatin, cytarabine, ginkgo biloba and other medications can be symptomatic treatment to improve the symptoms. 1. Physiological factors: Normal people will feel numbness in hands and feet when they are compressed or in a fixed position for a long time, and then they only need to release the compression or change the position to relieve the numbness, and need medication. 2. Pathological factors (1) Peripheral nerve injury: such as diabetes caused by peripheral nerve injury, cervical and lumbar spine disease leading to nerve root compression, etc., on the basis of controlling the primary disease, you can also follow the doctor’s instructions to take methylcobalamin, vitamin B1 and other nutritive nerve drugs. (2) Stroke: If the numbness of hands and feet is caused by stroke, it is necessary to take aspirin, atorvastatin and other anti-platelet aggregation, plaque stabilizing drugs, ginkgo biloba and other drugs to improve circulation, cytarabine and other drugs to promote the metabolism of brain cells. If the patient has paralysis of the hands and feet, he should go to the hospital in time to find out the cause and treat the symptoms, do not blindly self-medication.