Melanoma generally refers to malignant melanoma, which usually does not go away on its own and requires surgical excision treatment and chemotherapy, etc. Melanoma is a malignant tumor that originates from melanocytes and has a high degree of malignancy. It often occurs in areas such as the skin or the skin-mucous membrane junction, and its occurrence can be related to genetic and environmental factors. Melanoma often requires surgical treatment and chemotherapy. Surgical methods mainly include surgical excision and intraoperative lymph node localization or regional selective lymph node dissection. Extremity melanoma may be treated with localized perfusion chemotherapy, etc. In addition, radiation therapy, interferon and other specific immunotherapy are also effective. If there is any discomfort, prompt medical attention is recommended.