Infant fever fontanel bulge, may be due to acute upper respiratory tract infection caused by benign intracranial pressure increase, can also be seen in the intracranial infectious diseases, treatment in the choice of reasonable antipyretic at the same time, for the cause of fever treatment is also very important. 1 acute upper respiratory tract infection: fever fontanel bulge can occur, most of the mild bulge, the baby’s general condition is good, when the baby’s body temperature returns to normal, fontanel can be restored. Treatment in the reasonable antipyretic treatment (such as physical cooling or drug antipyretic) at the same time, need to target the pathogen for treatment. If the fever is caused by bacterial infection, antibacterial drugs such as cefaclor and cefdinir should be actively used for anti-infection treatment. If the fever is caused by viral infection, anti-viral treatment should be carried out with drugs such as pediatric cold and flu granules. 2. Intracranial infections: such as bacterial meningitis, clinical fever may appear, may be accompanied by convulsions and depression, the examination can be seen fontanel bulging, improve the cranial nuclear magnetic and lumbar puncture examination can help diagnosis. The key to treatment is the timely and rational application of antibacterial drugs, commonly used drugs include ceftriaxone, cefotaxime, penicillin, vancomycin and so on. At the same time, glucocorticoids such as dexamethasone are used to reduce cerebral edema, lower intracranial pressure, increase cerebral blood flow and improve cerebral metabolism; furosemide, mannitol and other intracranial pressure treatments are used. The above drugs need to be used under the guidance of a physician. Infant fever fontanel bulge can also be seen in a variety of diseases, the need to consult a specialist physician for comprehensive judgment and treatment.